Wine

32-bit and 64-bit Support

On x86_64-linux, the wine package supports by default both 32- and 64-bit applications. On every other platform, the wine package supports by default only 32-bit applications.

These defaults can however be overwritten like this:

{
  environment.systemPackages = with pkgs; [
    # ...

    # support both 32- and 64-bit applications
    (wine.override { wineBuild = "wineWow"; })

    # support 32-bit only
    # (wine.override { wineBuild = "wine32"; })

    # support 64-bit only
    # (wine.override { wineBuild = "wine64"; })

    # wineStaging accepts the wineBuild argument, too
    # (wineStaging.override { wineBuild = "wineWow"; })
  ];
}

If you get the error wine: '/path/to/your/wineprefix' is a 64-bit installation, it cannot be used with a 32-bit wineserver., then you need the 64-bit ("wineWow") build.

The override method is mentioned in the manual.