Wine

32-bit and 64-bit Support

On x86_64-linux, the wine package supports by default both 32- and 64-bit applications. On every other platform, the wine package supports by default only 32-bit applications.

These defaults can however be overwritten like this:

{
  environment.systemPackages = with pkgs; [
    # ...

    # support both 32- and 64-bit applications
    wineWowPackages.stable

    # support 32-bit only
    wine

    # support 64-bit only
    (wine.override { wineBuild = "wine64"; })

    # wine-staging (version with experimental features)
    wineWowPackages.staging

    # winetricks and other programs depending on wine need to use the same wine version
    (winetricks.override { wine = wineWowPackages.staging; })

    # native wayland support (unstable)
    wineWowPackages.waylandFull
  ];
}

If you get the error wine: '/path/to/your/wineprefix' is a 64-bit installation, it cannot be used with a 32-bit wineserver., then you need a 64-bit build like wineWowPackages.

The override method is mentioned in the manual.